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Past Events

September 1–2, 2025 · Okura Hotel · Kyoto, Japan

Satellite Meeting to the International Congress of Inborn Errors of Metabolism (ICIEM)

Overview

The 6th International Symposium on Urea Cycle Disorders (UCD) brought together a global, multidisciplinary community to share new scientific insights and strengthen international collaboration. Held September 1–2, 2025 at the Okura Hotel in Kyoto, Japan, the meeting convened 134 attendees from 21 countries.

The event was jointly organized by the:

  • Urea Cycle Disorders Consortium (UCDC)
  • National Urea Cycle Disorders Foundation (NUCDF)
  • Citrin Foundation (CF)
  • European Registry and Network for Intoxication Type Metabolic Disorders (E IMD)
  • Japanese Society for Inherited Metabolic Disorders (JSIMD)

Participants represented a diverse range of expertise, including physicians, physician scientists, basic and translational researchers, industry representatives, patient advocates, dieticians, neuropsychologists, study coordinators, and trainees.

Program Highlights

Welcome Reception & Poster Viewing

The symposium opened with an evening reception featuring a poster session that encouraged early networking, scientific discussion, and interaction across clinical, research, and advocacy sectors.

Meet the Professor Session

Trainees and junior investigators participated in an interactive mentorship forum with senior experts, fostering career development and scientific exchange.

Scientific Program

Internationally recognized speakers presented advances across four central themes:

  • Disease Models and Mechanisms
    New insights into UCD pathophysiology and experimental systems.
  • Phenotypic Diversity & Personalized Medicine
    Exploration of clinical variability and individualized approaches to care.
  • Innovative vs. Established Therapies
    Comparative perspectives on emerging treatment options and standard practices.
  • Challenges in Newborn Screening
    Strategies and opportunities to improve early detection and diagnosis.

Collaboration & Community

Throughout the two day event, attendees engaged in both structured and informal networking that strengthened partnerships across clinical, scientific, industry, and advocacy communities. The multidisciplinary nature of participation enriched discussion and reinforced the importance of collaborative approaches to advancing UCD research and care.

The 6th International Symposium on Urea Cycle Disorders successfully advanced global scientific dialogue, supported emerging investigators, and reaffirmed the international community’s commitment to improving outcomes for individuals affected by UCDs. With 134 participants from 21 countries, the meeting marked another significant step forward in UCD research, clinical innovation, and global collaboration.

UCDC Event Banner for the 5th International Symposium on Urea Cycle Disorders

Day 1: Overview and International Perspectives: Clinical Experience and Poster Presentations
Session Co-Chairs: Matthias Baumgartner, MD, University Children’s Hospital, Zurich, Gerard Berry, MD, Boston Children’s Hospital & Cynthia Le Mons, National Urea Cycle Disorders Foundation

Day 2: Biomarkers and Outcomes: Clinical Trial Readiness and Meet the Professor Session for Trainees and Junior Faculty
Session Co-Chairs: Lindsay Burrage, MD, PhD, Baylor College of Medicine & Andrea Gropman, MD, Children’s National Hospital

Day 3: Diagnosis and Therapies and Networking Closing Reception
Session Co-Chairs: Sandesh Nagamani, MD, Baylor College of Medicine & Oleg Shchelochkov, MD, US National Institutes of Health

Symposium Co-Chairs: Andrea Gropman, MD, and Cynthia Le Mons

View the Recorded Lectures.

This event was hosted by the Urea Cycle Disorders Consortium (UCDC), the National Urea Cycle Disorders Foundation (NUCDF), and the European Registry and Network for Intoxication Type Metabolic Diseases (E-IMD) in collaboration with metabolic colleagues from around the globe as a satellite meeting to the 14th International Congress on Inborn Errors of Metabolism 2021. Registration fees, a grant from the US National Institutes of Health, and UCDC and NUCDF support will cover the cost of the event.

Accreditation Statement: This live educational activity has been planned and implemented in accordance with the accreditation requirements and policies of the Medical Society of Virginia (MSV) through the joint providership of Inova Office of Continuing Medical Education and Children's National Medical Center. The Inova Office Continuing Medical Education is accredited by the Medical Society of Virginia to provide continuing education for physicians.

Credit Designation: The Inova Office of Continuing Medical Education designates this live activity for a maximum of 8.25 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity. Physicians may claim up to 8.25 credits in Type 1 CME on the Virginia Board of Medicine Continued Competency and Assessment Form required for renewal of an active medical license in Virginia.

The 5th International Symposium on Urea Cycle Disorders is a satellite to the 14th International Congress of Inborn Errors of Metabolism | 21-23 November 2021